In April 2006, the Indiana State Library hosted its inaugural Indiana Vision Expo for persons with vision loss, their friends and families, service providers, educators, health care professionals, librarians, and other consumers interested in products and services designed to promote independent living. That first year, fifteen vendors exhibited and sold a variety of products from computer software and magnifiers to games and kitchen gadgets, and promoted services available to people with visual impairments.

The Vision Expo has been more successful than anticipated. In its first year, over 500 people attended, and the vendors reported that this was the busiest Indiana-based trade show they ever worked. This innaugural event laid the groundwork for a larger Expo in 2007 with over 600 attendees and 20 vendors. The Expo now welcomes over 40 vendors and 1,000 attendees annually making it the largest low-vision trade show in the Midwest.